TY - JOUR T1 - Effect of Diazinon as a pesticide on oogenesis and ovary structure of Balb/C mice strain TT - تأثیر آفت‌کش دیازینون بر اووژنز و ساختار تخمدان موش‌های نژاد Balb/C JF - jsci JO - jsci VL - 8 IS - 2 UR - http://jsci.khu.ac.ir/article-1-1230-en.html Y1 - 2009 SP - 143 EP - 152 KW - Oogenesis KW - Diazinon 60% EC KW - Balb C mice N2 - Diazinon is a contact organophosphorous pesticide which has a wide range of insecticidal application. In this study the effects of diazinon 60% EC (Emulsifiable concentrate) on oogenesis and ovary structure of mature and immature Balb/C mice were assessed. Olive oil was used as solvent. The lethal dose (LD50) was estimated as 68 mg/kgB.W. Mice were divided into three groups: control, sham and experimental. In experimental groups of mature (>50 days old) and immature (~30 days old), 40 mg/kgB.W of diazinon 60% EC were injected intraperitoneally once a day for 7 days. In sham groups, the same amount of olive oil were injected once a day for 7 days. 8 days after the first injection in mature mice and three weeks after the first injection in immature mice, the animals were sacrificed and ovaries were removed and studied macroscopically and microscopically. 5 micrometer serial sections of ovary were made and stained with Hematoxylin and Eosin. Then, results were analyzed statistically. In the experimental groups of mature and immature mice, no significant alteration in the weight of ovary and blood level of FSH and LH were observed when compared with control groups. Significant decreases (P M3 ER -